It broke out around 2:45 a.m. on the 2900 block of Frankford Avenue.
Firefighters arrived to flames showing on the third floor rear bedroom.
Two women, ages 29 and 26, were injured after jumping from the burning house.
They were taken to the hospital in stable condition.
A 63-year-old man suffered second degree burns to the face and hands, officials say.
He was taken to Temple University Hospital in stable condition.
So far, no word on what sparked the blaze.