Gunfire erupted just before 3:00 a.m. Sunday along the 4900 block of Old York Road.
Police say an argument between several men broke out at a house party and spilled out into the street.
That's when the victim, believed to be in his late 20s or early 30s, was shot multiple times in the chest. He was taken to Albert Einstein Medical Center where he was pronounced dead.
One suspect was arrested.
Police are searching for two other men who took off from the scene moments after the shooting.