It happened shortly before 9:30 a.m. Thursday at Spring Valley and Temple roads.
At least one person was inside one of the vehicles when emergency crews arrived on the scene.
One of the vehicles involved had flipped on its roof. Chopper 6 was overhead as the car was positioned back on its wheels.
There is no word on injuries at this time.
State police tells drivers to avoid Springvalley Road between Temple and Brinton Lake.
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