It happened around 4:30 p.m. near the intersection of Jacobstown New Egypt and Meany roads in North Hanover Township, Burlington County.
Chopper 6 was over the wreck after an SUV and sedan collided.
North Hanover Township police say one juvenile was airlifted to Cooper University Hospital and is currently undergoing treatment. There is no immediate word on the victim's condition.
Four other juveniles, who were also in the vehicle, were hospitalized, but their injuries do not appear to be life-threatening, said police.
A woman in her 60s, who was in the other vehicle, suffered non-life-threatening injuries in the crash.
Police are still working to determine what caused the collision.