Her cousin, Jennell Allen, said Tuesday that Honeywood died in a Los Angeles hospital on Sunday after a two-year battle with cancer.
Bill Cosby told The Associated Press he met Honeywood decades ago after seeing her postcard illustrations.
Several of Honeywood's paintings were placed on the walls of the set of the hit comedy series, "The Cosby Show" and Cosby worked with her on a subsequent book series, "Little Bill."
Honeywood earned a master's degree from the University of Southern California and worked at the Joint Educational Project. She taught art to minority students.