The fire broke out just past 12:00 a.m. Tuesday on the 100 block of Germany Hollow Road.
Flames spread quickly and firefighters escalated the response to 3 alarms.
It took over two hours to place the blaze under control.
At least 3 families, 10 people including 4 children under the age of 5, are displaced. The Red Cross is assisting the occupants.
The manor house is a family home built in the 1700's, which also operates as a popular Bed and Breakfast.
No injuries have been reported at this time.