It happened in the 4500 block of North 19th Street at 2:17 p.m. on Wednesday.
Police say, when they arrived on the scene, they found a black male in his 40s with a gunshot wound to the chest and a black female in her 40s with a gunshot wound to the head.
Investigators are calling this a murder-suicide, however, it is not clear which person pulled the trigger.
The names of those involved have not been released.
