The incident happened where the freight rail tracks cross Aramingo Avenue at Castor Avenue.
Initial reports indicated that 2 tanker cars owned by the Union Tank Car Company jumped the tracks at 3:00 a.m.
A Conrail spokesperson later told Action News that 3 cars derailed, and crews were able to get one of the cars back on the tracks right away.
Two cars remained off the tracks for six hours after the incident happened, completely blocking Aramingo Avenue.
It was not immediately clear what caused the cars to derail.
Images from the Action Cam at the scene showed one set of wheels that appeared to have detached from one of the cars.
Signage indicated the tankers were carrying acetone, a flammable chemical solvent.
Fire crews inspected the cars and found nothing leaking from either tanker.
Police were on the scene diverting traffic off of Aramingo Avenue until the road finally reopened before 9:00 a.m.
No injuries were reported.