It happened before 12 a.m. Monday on Moore Street near South Hollywood Street.
Officers arrived to find the 17-year-old boy shot multiple times.
They put him a police cruiser and took him to Penn Presbyterian Medical Center, where he remains in critical condition.
Witnesses told police they say a dark-color vehicle fleeing the scene after the gunfire erupted.
Investigators are checking for surveillance video that may have captured the incident.
Stay with Action News and 6abc.com for more information as it becomes available.