The fire broke out just after 6:30 p.m. Tuesday in the 3600 block of North Marvine Street.
Cell phone video showed fire crews trying to resuscitate the woman after being pulled from the burning home.
"I was just scared for whoever was in there, it was just real crazy, and it was so fast," neighbor Shaheed Smith said.
Fast moving flames ripped through the row home's second floor.
Uber driver Jayci Mollichella of Clifton Heights, Pa. captured chaotic moments when she passed by the inferno.
"It was just, I can't explain it, just flames, the entire back of the house was just lit," Mollichella said.
The fire was tamed within 20 minutes.
Newly sworn in Philadelphia Fire Commissioner Adam Thiel says the victim, in her 20s, was taken to Temple University Hospital with severe smoke inhalation.
"Right now, the occupant is breathing on her own and is expected to survive," Thiel said.
Though Thiel calls this fire a "save" that wouldn't have happened without his team.
"This was a very fast, aggressive, outstanding firefighting effort. It does look like a number of the members from these companies will be recommended for heroism awards and rightfully so," Thiel said.
It's unclear if the woman had a working smoke detector or how the fire started.
Investigators say she was the only occupant to be rescued from the home as all others were accounted for.
A cause is under investigation.