Separated by plexiglass and 12 feet of space, Harris and Pence argued the merits of their respective party's candidates for President, Democrat Joe Biden and incumbent Republican Donald Trump.
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The COVID-19 pandemic was arguably the topic of the night, setting off a fiery exchange between the two just moments into the debate.
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Trump tested positve for COVID-19 last week along with a number of other White House staffers and three GOP senators, leading many to question the Trump admin's response to the pandemic.
So how did the candidates do?
Let us know how you feel in our post-debate poll question below.
If you cannot see our web polls, vote on Twitter.
Who do you think won the VP debate?— Action News on 6abc (@6abc) October 8, 2020