Boykin injured his right ankle last week during the Horned Frogs' 23-17 victory overKansas and had been listed as questionable all week.
Patterson told Rowe that redshirt freshman Foster Sawyer would get the start at quarterback against the seventh-ranked Sooners.
Sawyer replaced Boykin in TCU's win over Kansas. He completed just 1 of 7 passes, though his lone completion was a 42-yard touchdown to Shaun Nixon.
Earlier this week, Patterson said wide receiver Josh Doctson would miss the rest of the regular season with a wrist injury.
Boykin and Doctson both were named among the 15 semifinalists for the Walter Camp Player of the Year Award.
TCU to struggle without Boykin
Kirk Herbstreit and Lee Corso don't see how TCU beats Oklahoma without QB Trevone Boykin.
College football pick: TCU-Oklahoma
ESPN college football reporter Ted Miller makes his prediction for No. 18 TCU's trip to No. 7 Oklahoma. No line has been established for the game in Norman.