The crash happened at the intersection of Frosty Hollow Road and Upper Orchard Drive around 11:30 p.m.
Police say a red Acura, driven by Samuel Dick of Levittown, crossed the center lane and struck a gray Cadillac heading in the opposite direction.
The driver of the Cadillac, William Hogan, was pronounced dead at the scene.
Dick remains hospitalized in critical condition.
An investigation into this crash continues.