The 45-year-old Moyer had nine strikeouts for the first time since July 28, 2004, also against the A's while with Seattle, but Philadelphia saw its losing streak reach a season-high six games as the Phillies started a nine-game road trip that also takes them to Texas and Atlanta.
Blanton (4-10) allowed Pat Burrell's 19th home run in the fourth but didn't make many other mistakes in a solid 119-pitch performance. He avoided matching the worst losing streak of his career, a five-game skid in his rookie year of 2005. Blanton, who is the fastest pitcher to reach 10 losses in Oakland history, improved to 2-7 at home in the Coliseum. His quick work helped the game go just 2 hours, 24 minutes.
Alan Embree relieved in the eighth and allowed Ryan Howard's RBI single, but he struck out Burrell to end the inning. Houston Street pitched a 1-2-3 ninth for his 14th save in 17 chances after blowing the save Friday night against Florida and taking the loss Saturday.
Brown was 2-for-13 lifetime against Moyer (7-5) before connecting for his sixth homer.
After Kurt Suzuki led off the game with an infield single, Moyer didn't allow another hit until Ryan Sweeney's leadoff single in the seventh - the first of four hits off Moyer that inning. He walked Jack Hannahan in the second, then retired the next 13 A's batters in order. The soft-tossing left-hander got called third strikes on three consecutive batters, too, and struck out four in a row - including striking out the side in the sixth.
Philadelphia shortstop Jimmy Rollins returned home to the East Bay after playing in San Francisco last month. He grew up about 10 minutes away in Alameda and said he was leaving 24 tickets for family and friends.
"Don't call me, call my mom," said Rollins, who also played an interleague series in Oakland in 2005. "First come, first serve."
This marked the first game featuring two native Hawaiians from the island of Maui - Oakland catcher Suzuki and Phillies center fielder Shane Victorino. They grew up five minutes apart attending different high schools and Victorino went to kindergarten with Suzuki's big sister. Their parents had lunch together earlier Tuesday.
"Shane was probably stealing surfboards and not bases back then," Rollins joked.
Suzuki and Victorino patted each other on the back side when Victorino came to the plate in the first. He singled and then stole his 18th base in the eighth.
Oakland third baseman Eric Chavez was a late scratch because of a sore right shoulder that also kept him out Sunday.
A's hitting coach Ty Van Burkleo was ejected in the fifth by home plate umpire Jeff Nelson for arguing balls and strikes.
Notes: A's 2B Mark Ellis was not feeling well and didn't start. Suzuki batted leadoff in the spot where Ellis has been hitting. ... Phillies DH Geoff Jenkins saw his hitless streak reach 0-for-22 after going 0-for-4 with three strikeouts. ... Oakland RHP reliever Joey Devine, on the DL with inflammation in his throwing elbow, played catch from 200 feet and could throw off the mound as soon as Thursday. ... Oakland extended its errorless streak to a season-best eight games, but it took a change by the official scorer. 3B Hannahan bobbled a grounder by Jayson Werth in the seventh but it was later ruled a single.
