A security camera caught the action when two men closed in.
One held the door open as the other grabbed $5,500 worth of cash, and checks.
They ran out the door with a security guard and volunteers in hot pursuit, but they got away.
It's left everyone wondering, how low can you go?
While the search continues for the thieves, there was some good news for the charity.
Another tenant of Liberty Place, accounting firm Parente Rudolph, stepped up to replace the missing money.
The C.O.O. of the firm, Jeff Ferro, says he didn't hesitate when he heard about the theft.
"It was apalling at a time when non-profit organizations and organizations that are doing something for a cause need money now more than they ever have," Ferro said.
The news of the gift has restored the faith of the volunteers at Susan G. Komen.
"We have a wonderful organization, volunteers, and the people in our community are very special. So, I am very thankful," said volunteer Elaine Grobman.
The police are hoping someone turns in the thieves.
The Run for the Cure, meanwhile, will go on as planned on May 10th without losing a dime, thanks to individual and corporate generosity.
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