It happened here on the 3400 block of Saint Vincent Street in the Philadelphia's Mayfair just before 3:00 this morning.
When firefighters arrived, they encountered heavy flames on the second floor of the home.
Rescue crews found two women trapped in a bedroom in the back of the house.
The women were rushed to the hospital with burns and smoke inhalation. A third woman is being treated for smoke inhalation.
All three are in serious condition.
