Moyer only mistake was a two-run homer by Vernon Wells in the third inning. Moyer passed former Phillies Hall of Famer Robin Roberts for the most homers allowed in a career.
The Blue Jays made a season-high four errors, including a pair by second baseman Aaron Hill, that set up six unearned runs.
Jimmy Rollins, Shane Victorino and Ben Francisco each had three hits for the Phillies and Ryan Howard scored three runs. Philadelphia won for the eighth time in 11 games.
The 47-year-old Moyer (9-6), whose mound opponent wasn't even born when he made his major league debut, gave up two runs and six hits in seven innings. He struck out seven and walked none.
Moyer earned his 267th career victory, moving within one win of tying Jim Palmer for 34th on the all-time list. Moyer has won four of his last five starts.
Moyer made his big league debut on June 16, 1986, 16 days before Toronto starter Brett Cecil (7-5) was born.
The Phillies took two of three from the Jays in a series that was moved from Toronto to Philadelphia because of the G20 Summit. As they did all series, the Jays wore their home uniforms and batted second, while the Phillies wore their road grays.
Toronto has lost five of seven overall.
Cecil struggled for the third straight outing, allowing seven runs - five earned - and a season-high 10 hits in 4 2-3 innings.
Cecil won five straight starts, allowing only six earned runs, in a span through June 10. Since then, he has lost three in a row while giving up 25 hits and 16 earned runs in 15 2-3 innings.
The Phillies scored four times in the second, with Dane Sardinha hitting a two-run double and Francisco and Rollins adding RBI singles. Francisco also doubled twice.
After Toronto got a pair of runs back on Wells' 19th homer, the Phillies got both runs back in the fourth on RBI singles by Rollins and Chase Utley. Both were unearned after Hill dropped the throw from shortstop Alex Gonzalez on Wilson Valdez's sharply hit grounder that looked like a routine double-play ball that would've ended the inning.
Consecutive doubles by Howard and Victorino to open the fifth gave Philadelphia a 7-2 lead.
Hill had another gaffe in the strange seventh inning when the Blue Jays made three errors that set up four runs.
With one out, Howard was called safe when first-base umpire Joe West ruled that Lyle Overbay came off the bag on a throw, although replays appeared to show the first baseman held the bag. After Victorino singled and Francisco doubled, Raul Ibanez walked to load the bases.
The inning looked to be over when Valdez hit a sharp grounder to Hill, but the second baseman threw past Gonzalez and into left field, allowing Victorino and Francisco to score. Then, Sardinha grounded harmlessly to the pitcher's mound, but Jason Frasor threw it away trying to get Ibanez in a rundown, allowing another run to cross.
NOTES: Moyer became the 40th pitcher in major league history to reach 4,000 innings when he completed the second. ... Jayson Werth made two stellar defensive plays in right field, robbing Adam Lind of extra bases with a running catch in the second and diving to snare John McDonald's line drive in the fifth. ... The Phillies finished with a 9-9 interleague record, while Toronto went 7-11.
