Police say about 1:40 Thursday morning, a teenager opened fire on three men on the 4900 block of North Camac Street in the Logan section of the city.
One of the victims, a 50-year-old, is in the hospital in critical condition with a gunshot wound to the chest.
A 30-year-old is in serious condition with a neck wound.
The third man is nursing a graze wound.
Investigators say the shooter ran off and remains on the loose.
About 9:30 on Wednesday night, police say four people were shot on a street in the Frankford section of the city.
So far, officers are not saying who fired the shots at Bridge and Duffield streets, but the most seriously injured is a 21-year-old man.
He is in critical condition at Aria's Torresdale division, with face and neck wounds.
The three other shooting victims have non-life-threatening injuries.
Investigators have not indicated if they have any motives in the shootings, or suspects.