The 97-year-old woman was rushed to Cooper University Hospital in an unknown condition.
Neighbors say they were able to get into the house and pull the woman out. She was said to be badly burned, but conscious.
The explosion happened near the intersection of Edgewood Lane and Nassau Road shortly before 9:30 p.m.
Neighbors say they heard a loud boom that shook the city and surrounding areas.
"They were watching the Flyers game, everything came off the shelf in the house, it blew out a couple windows across the street, it was bad," neighbor Jackie Larmanis said.
"I was freaking out. I thought somebody crashed on the roof or a meteor hit out back, that's how loud it was. There was like a big boom and the whole house shook, the whole neighborhood shook," neighbor Bobby Dorizio said.
The home was completely destroyed in the explosion.
The surrounding homes suffered significant damage and authorities say those residents may be displaced for some time.
Public Service Electric and Gas is investigating the cause of the explosion. They are looking into whether it was a gas explosion.
Action News viewers called into the newsroom shortly after the explosion saying they felt the effects from as far away as Northeast Philadelphia and Columbus, New Jersey.