One night after beating Roy Halladay, the Brewers took a 3-0 lead into the sixth against Cliff Lee and were trying to complete their first ever sweep in Philadelphia.
But Polanco connected off starter Chris Narveson to tie it in the sixth. Victorino then hit a long drive to deep right-center off Brandon Kintzler (1-1) to put the Phillies up 4-3.
Ryan Madson (2-0) pitched a scoreless eighth to earn the win and Jose Contreras finished for his fourth save in four tries.
Second baseman Wilson Valdez helped Contreras by making an outstanding over-the-shoulder catch on a shallow looper to right by Carlos Gomez with one out in the ninth. Contreras then struck out Ryan Braun swinging on a 95 mph fastball to end it.
Prince Fielder had three hits and two RBIs and Jonathan Lucroy hit a solo homer for the Brewers, who tagged Lee for three runs - two earned - and eight hits in six innings. Lee had just one strikeout coming off a 12-strikeout shutout at Washington last Thursday.
Narveson didn't allow a hit until John Mayberry Jr. lined a double to left with two outs in the fifth. The lefty took a one-hitter into the sixth before the Phillies rallied. He left after giving up three runs and four hits in six innings.
The Brewers won the series opener 6-3 in 12 innings, despite a blown save in the ninth by closer John Axford. They battered Halladay in a 9-0 win Wednesday night, becoming the first team to beat the NL East-leading Phillies in a series this season.
Valdez got the Phillies started with a walk in the sixth. One out later, Victorino singled through the second-base hole on a perfectly executed hit-and-run. That brought up Polanco, who fell behind 0-2 before launching a drive a couple rows deep into the left-field seats to tie it 3-3. The runs snapped a 17-inning scoreless streak for the Phillies.
The Brewers became the first team to score a first-inning run against Philadelphia this season on Fielder's RBI infield single. Gomez hit a one-out single, advanced to third on Braun's single and scored on Fielder's grounder up the middle that Valdez knocked down.
Milwaukee added an unearned run in a goofy third inning. Braun hit a two-out popup down the right-field line that Valdez dropped. Fielder then ripped a double to left-center, and Braun ran right through third-base coach Ed Sedar's stop sign and slid safely under a throw that beat him for a 2-0 lead.
Casey McGehee followed with a single to right but got caught rounding the bag to end the inning. Rickie Weeks also made a blunder that inning when he led off with a grounder down the first-base line that was a few feet foul off the bat, so he didn't run. The ball hit a cutout, rolled fair and Ryan Howard picked it up to record the out.
Lucroy lined a 1-1 cutter into the seats in left to make it 3-0 in the fourth.
Notes: Braun has reached safely in all 18 games this season. The team record to start a season is 23 by Hall of Famer Robin Yount in 1983. ... A crowd of 45,743 was the 147th straight sellout at Citizens Bank Park, including postseason. ... The Brewers are 15-32 in Philadelphia. ... Former Phillies pitcher Art Mahaffey threw out the first pitch on the 50th anniversary of his club-record, 17-strikeout performance against the Chicago Cubs on April 23, 1961. ... Polanco is 10 for 21 with runners in scoring position.
