The car they were in veered off of the 4600 block of the Roosevelt Boulevard, hit a tree, and slammed into a wall.
The crash was reported to emergency crews around 3:45 Saturday morning.
Firefighters freed the women from the wreckage, near Friends Hospital.
All of the victims are expected to survive, according to investigators.
Three of the women are being treated at Einstein Medical Center... the other woman is being cared for Aria Hospital-Torresdale.
The cause of the crash remains under investigation.