Josh Bailey, Matt Moulson, Mark Streit and Michael Grabner scored to help the Islanders also break an eight-game losing streak against Philadelphia, which had won 23 of its previous 24 games against the Islanders.
The victory was the Islanders' third in their last four games, and it marked the first time New York won in Philadelphia since April 7, 2007, a 4-2 victory.
Matt Read scored for Philadelphia.
