The Owls (21-5, 10-2) won their 10th straight to stay atop the A-10 (21-5, 10-2). Duquesne fell to 15-11, 6-6 in A-10 play.
Wyatt and Fernandez combined for 18 of Temple's 30 field goals. Wyatt was 11 for 17 from the floor and grabbed five rebounds. Fernandez, who made 7 of 9 shots from the field, hit six of his seven treys.
Temple shot 57.7 percent from the floor (30 of 52). The Dukes, meanwhile, shot just 36.5 percent (23 of 63). Guard B.J. Monteiro, was the only Duke in double figures, with 20 points on 8-of-16 shooting.
Temple was 10 of 19 from beyond the arc, Duquesne 5 of 17. The Owls had 20 assists (eight by Ramone Moore, six by Fernandez) to nine for Duquesne.