It happened Sunday morning at the intersection of U.S. 13 and Camp Road.
Police say 21-year-old Corey McKelvey failed to stop or yield and drove his car into the path of a car driven by 26-year-old Michael McFarland.
McKelvey and his passenger, 18-year-old Brittany Jefferson, were flown to Christiana Hospital. McFarland was taken to a local hospital.
Police say it's unknown whether alcohol was involved, and charges are pending.
