The accident happened shortly after 7:00 p.m. at 9th Street and the Boulevard in the Hunting Park section of Philadelphia.
Police say a vehicle overturned in the southbound lanes, trapping the driver inside.
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Police and medics responded and pulled the 25-year-old man from the wreckage.
He was rushed by medics to Albert Einstein Medical Center in critical condition. He was pronounced dead a short time later.
There is no word on what caused the man to lose control.
Southbound Roosevelt Boulevard was closed for close to an hour.
Police continue to investigate.
