Rescuers were called to the Tyler McConnell Bridge shortly after 10:00 a.m. for a report of a person in the Brandywine River.
Rescuers on the scene initially told Action News that the woman's husband jumped in after her.
However, two workers from the nearby Hagley Museum and Library said they were outside when they heard a splash and it was one of those workers who went in the water after the woman.
Those workers said they saw a man yelling a woman's name from the bridge.
The library worker who went in the water couldn't reach the woman and returned to shore.
When rescuers arrived they were able to reach the woman and rushed her to the hospital. There was no word on her condition.
The person who jumped in the water after the woman was not injured.
Police are investigating this incident.
The bridge was closed in one direction during the rescue operation.