The incident happened around 11:30 p.m. at the intersection of Broadway and Kaighn Avenue.
Officials say a driver tried to evict 3 female passengers after a disturbance on the bus.
The women then allegedly began punching the driver in the face several times before fleeing from the bus.
The driver was taken to the hospital and treated and released.
Police are hoping the surveillance video will give them a description of the three women.