Biden and his family appeared onstage at the Kennedy Center on Sunday night to help open the Latino Inaugural 2013 concert.
Biden says something "profound" happened with the enormous Latino support for Obama, and he says the Latino community underestimates its power.
He told the audience that they "spoke in a way that the world ... could not fail to hear."
Biden said "America owes" Latinos and declared, "This is your moment"
Singer Jose Feliciano opened the show by singing the national anthem. Actress Eva Longoria, a co-chairwoman for Obama's campaign, is hosting the event, which also includes Antonio Banderas, Rosario Dawson, Marc Anthony and Rita Moreno.