The fire broke out around 3:30 a.m. on the 2400 block of North 54th Street.
Crews arrived to heavy fire on the first floor of the single family house.
The second floor was consumed with smoke - flames were seen in the rear of the property and fire burst through the roof.
Officials believe the house was vacant and there are no reports of injuries.
The Fire Marshal was called to the scene to investigate the cause of the blaze.