The fire broke out around 12:30 a.m. Tuesday in the 5600 block of Baynton Street.
Crews arrived to find heavy fire on the second and third floors of the house.
At some point fire officials say a 49-year-old woman jumped from a second floor window to escape the flames.
The woman was rushed to an area hospital with a broken hip and head injuries.
She is listed in critical but stable condition.
Fire investigators are working to determine what sparked the blaze.