It happened at 9:49 p.m. Sunday.
Police say Jerome Lewis, 20, of New Castle, was driving a 2002 Volkswagen Jetta south on South DuPont Highway (Route 13) when he collided head-on with a 2003 Dodge Ram pickup truck, driven by Larry Boerner, 36, of Keyport, NJ.
Police say Boerner was traveling north in the southbound lanes when the crash happened near Second Avenue.
Police say Lewis was wearing a seatbelt. It took firefighters about half an hour to free him from the wreckage. He was rushed to Christiana Hospital with injuries to his head, arms and legs.
Boerner was taken to Christiana Hospital with non-life-threatening injuries. His two passengers, Desiree Dejesus, 26, and Christian Boerner, 2, both of New Castle, were also hurt.
Dejesus was taken to Christiana Hospital by ambulance with leg and head injuries. Christian Boerner suffered a serious head injury. The boy was rushed to Christiana Hospital, then transferred to A. I. duPont Hospital for Children.
There was no immediate word on what charges, if any, would be filed.
Traffic on South DuPont Highwaty was backed up for an hour and half while police investigated and crews worked to clear the scene.