The accident happened at 6:30 a.m. on the ramp leading from I-76 West to Route 202 South and 422 West in King of Prussia.
The truck, which was hauling debris, overturned on a curve.
The driver was able to get out safely and was not injured.
Traffic on the westbound expressway was backed up for several hours as crews worked to right the truck and clear the scene.
The ramp was fully reopened by 11:30 a.m.
State police have impounded the truck. No word what charges, if any, might be filed.