The accident happened around 11:30 p.m. on the southbound lanes at Fox Street in the city's East Fall section.
Police say two vehicles crashed and the force of that collision flipped an SUV onto its roof.
Three cars, right behind the crash couldn't stop in time and ran into each other.
Three people were injured and taken to the hospital for treatment.
They suffered from neck and back injuries and all are listed in stable condition.
The crash is under investigation.