It happened around 11:00 a.m. Saturday on Route 563 near Lake Nockamixon.
Authorities say 61-year-old Edward Manning of Kintnersville was traveling north when he lost control of his 2005 Hyundai Sonata, crossed over the southbound lanes and crashed into a tree. Manning was pronounced dead at the scene.
Police are still trying to determine the cause for the crash.