The crash happened at 11:16 a.m. Monday in the 1400 block of Manley Road.
Police say the bike was heading eastbound and hit a car leaving the Summit House Condominium complex.
The biker was thrown, hitting a mailbox and a telephone pole.
That biker, whose identity has not been released, was pronounced dead at the scene.
The driver of the car was not hurt.
The crash remains under investigation. Anyone who witnessed the crash is asked to contact the Westtown-East Goshen Regional Police Department at 610-692-9600.