It appeared the dead were the pilot and one person in the house, said a deputy fire chief, Kevin Brame. Another person in the house was taken to University Medical Center in Las Vegas in critical condition, he said.
The rear-propeller Velocity 173 RG aircraft crashed about 6:30 a.m. after taking off from the North Las Vegas airport, Federal Aviation Administration spokesman Ian Gregor said.
The pilot radioed that he wasn't gaining altitude and was going to crash, he said.
Firefighters quickly doused the intense fire in the single-family home, in a neighborhood not far from the end of the airport runway, Brame said.
The aircraft was certified for flight in 2002 and was owned by a Las Vegas resident. No names have been released.