The entertainment reporter said Thursday she will wrap up her 13-year run on the NBC show this week.
Publicist Annie Jeeves says O'Dell is pursuing a new opportunity but did not elaborate.
O'Dell has been a reporter on "Access Hollywood" since the show began in 1996. She has also played a reporter on several TV shows and appeared as a contestant on "Dancing With the Stars."
O'Dell says she will still host NBC's coverage of the Tournament of Roses parade on New Year's Day.