The fire broke out along 16th Street near Cecil B. Moore Avenue shortly before 8:30 p.m.
Arriving fire crews reported seeing medium to heavy smoke coming from the second and third floors of a three story row-style building.
One person was rushed by medics to Hahnemann Hospital for treatment of smoke inhalation.
There is no word yet on a cause.
The fire was brought under control around 9:00 p.m.
