Sesame Workshop has announced that Winfrey will voice an animated segment called "The O Show." In the spoof, the letter O will host her own talk show with guests including Otto the Orangutan and Ophelia the Octopus.
"Sesame Street" debuts its 41st season on Sept. 27 on PBS.
Other celebrities taking part during the season include Wanda Sykes, Jason Bateman, Colin Farrell and Katy Perry.
