Vick needed X-rays in the locker room after he was hit in the first quarter, and did not return to the bench for the second half. He will have an MRI on Monday.
"He's got a sore chest is what I can tell you right now," coach Andy Reid said.
Vick scrambled 23 yards, but was sandwiched on a hard hit by Kareem Moore and DeAngelo Hall and was slow to get up late in the first quarter. Kevin Kolb, the No. 1 QB when the season started, quickly warmed up and was in on the next play.
Vick's run was wiped out on a holding penalty by guard Max Jean-Gilles.
Vick declined to speak to the media.
Kolb suffered a concussion in the season opener, allowing Vick to take over the job.
Vick was sensational as the starter. He had 750 yards passing, six touchdowns and no interceptions, and had also run for 170 yards and one score in 10 quarters. For his efforts, Vick earned NFC offensive player of the month honors.
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He was 5 for 7 for 49 yards passing and rushed three times for 17 yards against the Redskins.
He was a three-time Pro Bowl quarterback during six seasons in Atlanta.
Vick missed the next two seasons while serving an 18-month sentence in federal prison for his role in a dogfighting operation. His dazzling play and reformed personal image - he tours schools speaking out against dogfighting - has made him a fan favorite in Philadelphia. Fans bring signs touting "Vickadelphia!"
In Donovan McNabb's return to Philadelphia on Sunday, one fan made a sign that read: "Goodbye McNabb, Hello Vick-tory!"