Police were called to The Plaza by hotel security at about 2 a.m. and Sheen appeared highly intoxicated, the official said. The actor was not arrested and went voluntarily. The official was not authorized to speak publicly about the encounter and spoke to the AP on condition of anonymity.
Sheen's publicist Stan Rosenfield said the 45-year-old was expected to be released Wednesday.
"Charlie had an adverse allergic reaction to some medication and was taken to the hospital," he said.
Police haven't received any complaints from the hotel about any possible damage. A message left with the historic hotel at the foot of Central Park wasn't returned.
It's not clear who the woman in the hotel room was. Sheen was reportedly in New York on a family vacation with his ex-wife, Denise Richards, and their two children, Sam, 6, and Lola, 5.
Sheen, the star of CBS' "Two and a Half Men," has had problems with alcohol and drugs in the past.
In August, he pleaded guilty in Aspen, Colo., to misdemeanor third-degree assault after a Christmas Day altercation with his wife, Brooke Mueller Sheen. Prosecutors dropped more serious charges and he avoided jail time and he was sentenced to 30 days in a rehabilitation center, 30 days of probation and 36 hours of anger management.
Mueller Sheen, who is the mother of twins with Sheen, told police that the actor threatened to kill her and brandished a knife after she told him she wanted a divorce. Charlie Sheen said they argued but he denied threatening her, and he told police that he was upset by the divorce threat.
He previously went through a bitter divorce and custody battle with Richards. Her publicist said Tuesday she had no comment on Tuesday's hotel encounter.
In December 1996, Sheen was charged with attacking a girlfriend at his Southern California home. He later pleaded no contest and was placed on two years of probation.
In 1998, his father, actor Martin Sheen, turned him in for violating parole after a cocaine overdose sent him to the hospital. He was ordered to undergo a rehabilitation program.
Sheen is also the star of films such as "Platoon," "Wall Street" and "Hot Shots!"