But several nominations for Eminem are about as sure a bet as one can make when the nominations are revealed Wednesday night at Club Nokia in Los Angeles. His critically acclaimed album "Recovery" marked a huge comeback for the rapper and has become the best-selling CD of the year so far.
Lady Antebellum is also a heavy favorite for multiple nominations, thanks to their No. 1 smash "Need You Now."
American Music Award favorite Justin Bieber, B.o.B, Miranda Lambert and Katy Perry may also get key Grammy nominations.
The Recording Academy will announce a handful of its 100-plus Grammy categories during a live, hourlong CBS broadcast; the rest will be released immediately afterward.