The accident between a tractor trailer and a car occurred around 2:30 a.m. in the southbound lanes of Interstate 295 near exit 30.
The impact of the crash caused the tractor trailer to flip over into one of the northbound lanes.
Two people were transported to Cooper Hospital in Camden for injuries.
Sources tell Action News that the tractor trailer was carrying glass bottles.
The impact of the crash forced New Jersey State Police to close down the southbound lanes and one northbound lane for several hours.