His 18 nominations include MVP of the Year, Best Live Performer and Hustler of the Year.
Lil Wayne's album "Tha Carter IV" debuted Aug. 29 at No. 1 on Billboard's Top 200 charts, selling 964,000 for the second-best first-week sales of the year behind Lady Gaga.
The sixth annual awards ceremony will be taped at Atlanta's Boisfeuillet Jones Atlanta Civic Center and broadcast Oct. 11. Actor and comedian Mike Epps will host.
Kanye West and Wiz Khalifa each had nine nominations, while Miami-based rapper Rick Ross followed up with eight.