Chopper 6 HD was over the scene just before 6:00 p.m. at Eldriges Hill and Marl roads in South Harrsion.
Officials say the driver of a tractor trailer lost control of the vehicle.
The cab of the trailer came to a rest overturned.
One person has been pronounced dead at the scene.
The roadway has been shut down in both directions.
The truck was carrying produce.