Action News is told that one person was killed.
It happened after 5:00 a.m. Monday on Route 309 South at Pumping Station Road.
Police say the pickup truck rear-ended the bus, trapping the driver.
Images from Chopper 6 HD over the scene showed a light-colored pickup truck with heavy front-end damage behind the bus.
Route 309 South remained closed at the scene as police investigated.
Stay with Action News and 6abc.com for more information as it becomes available.