It happened about 1:50 p.m. Tuesday. Troopers said in a news release that 49-year-old Joseph Waples of Ellendale was driving the truck when he entered a center crossover, stopped at a stop sign and continued onto Route 1.
Police say the truck entered the path of a minivan driven by 72-year-old Margaret Clift of Lewes. Authorities say Clift's vehicle struck the rear tires of the truck.
Troopers say Margaret Clift died at a hospital. Her husband, 73-year-old James Clift, a passenger in the minivan, was taken to a hospital with injuries that are not believed to be life-threatening.
The crash is under investigation.