CHOP shared its vision during a community meeting Wednesday night at the Philadelphia School.
The room was full as residents listened to plans of a skyscraper to be built in South Philadelphia.
Phase one of the project includes a 23 story tower that would be used for administrative purposes and offices for research.
It is the first phase of several planned buildings.
CHOP revealed renderings of the tall building that would be located at 700 Schuylkill Avenue on the east side of the river.
While some welcomed the idea of one the nation's top hospitals moving in, others took raised concerns about increased traffic, safety and access to the river.
Lauren Vidas is with the South of South Neighborhood Association.
"It is such a large development, and it is going to impact our neighborhood in such a way we're talking about thousands of square foot in a pretty dense residential area," said Vidas.
There were also questions about the parking garage obstructing neighbors view.
"It's a big giant 17 to 28 foot giant wall. It's pretty ominous for any part if the city, and certainly on this vibrant part the gateway to our neighborhood," said James Templeton.
The blaring concern was increased traffic to the area and how it would affect the South Street Bridge, but CHOP says most of their employees will not be travelling by car.
"We really expect only 25 percent of the employees in this building to actually need the parking garage," said Peter Grollman. "We've spoke with SEPTA, and we are committed to putting in a bike share and a bike rack."
The hospital goes before the Zoning Board April 16th.