The crash happened in the southbound lanes of I-91 near exit 21 in Middletown.
Connecticut State Police said the crash involved at least 20 cars, three tractor trailers and a tanker truck. No serious injuries were reported.
Troopers posted this video of the scene on social media:
I-91 southbound was shut down between exit 21 and exit 25.
The state police reported multiple crashes and spin-outs across the state.