Chaniece Benn was last seen around 3:54 a.m. Saturday at Mercy Philadelphia Hospital in the 500 block of South 54th Street leaving with an unknown male.
Benn is a resident in the 3800 block of Aspen Street.
She suffers from cerebral palsy and has a diminished mental capacity.
Benn is described as 5' 1'' and 130 lbs. with a medium build, brown eyes, light brown complexion and straight black, shoulder-length hair.
She was last seen wearing a black hooded jacket, khaki pants, black shirt and black sneakers with a silver stripe.
The male she was last seen with is described as a black male, 5' 5'' with medium build, medium complexion, wearing a gray hooded sweatshirt, blue jeans and black shoes.
Anyone with information can contact police at 215-686-3183 or call 911.